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Why Three Families Entered Kids in a COVID Vaccine Trial  - web md

Why Three Families Entered Kids in a COVID Vaccine Trial

Before signing up, parents should ask about the time commitment, trial leaders say, including the number of visits, the follow-up period, and other details. Parents will be expected to record detailed information, such as whether children have side effects such as fevers.
web md - 2 days ago
How to Deal With Toxic Parents  - web md

How to Deal With Toxic Parents

Not every parent-child relationship is healthy. If you have a toxic parent it can be hard to shed the child role and look after yourself. Learn how to spot toxic parental behavior, lose guilt, set boundaries, and practice self-care.
web md - 2 days ago
Toxic Family Members: How to Deal With Them  - web md

Toxic Family Members: How to Deal With Them

Not every family fits the happy, loving ideal. For some, family dynamics are downright unhealthy, or even dangerous. Learn how to spot toxic behavior, shed guilt, put up boundaries, and keep distance to safeguard your own well-being.
web md - 3 days ago
Regeron Antibody Cocktail Offers COVID Protection  - web md

Regeron Antibody Cocktail Offers COVID Protection

In its statement, Regeneron said it would ask the U.S. Food and Drug Administration to expand the drug's emergency authorization use -- for high-risk people who already have COVID-19 but are not hospitalized
web md - 4 days ago
Free Webinar: Create a happy workplace in ANY industry - positive sharing

Free Webinar: Create a happy workplace in ANY industry

Everyone who cares about workplace happiness has heard about Google, Zappos and Southwest Airlines. But have you ever heard of the call center Contento in Colombia? I hadn’t until I spoke at a conference in Chile and met the awesome Nicolas Gonzalez Restrepo and heard what a great culture he’s helped create for the 2,000 … Continue reading Free Webinar: Create a happy workplace in ANY industry →
My Spouse Is Depressed: Tips on How to Help and Cope  - web md

My Spouse Is Depressed: Tips on How to Help and Cope

Is your spouse depressed? If your loved one withdraws from activities or sex, spends more time alone, or drinks more alcohol than they once did, they may have depression. Find out what to do if your partner refuses to get therapy and get tips to protect your own mental health.
web md - 1 week ago
Millennials Flock to Telehealth, Online Research  - web md

Millennials Flock to Telehealth, Online Research

A new survey of 2,040 millennials (ages 23 to 39) found that 69% of respondents searched online for health and medical advice instead of going to the doctor, and a quarter of respondents trust Google to accurately diagnose their symptoms.
web md - 2 weeks ago
An emerging treatment option for men with recurring prostate cancer after radiation therapy - harvard

An emerging treatment option for men with recurring prostate cancer after radiation therapy

Prostate cancer is often a multifocal disease, meaning that several tumors can be present in different parts of gland at the same time. Not all of these tumors are equally problematic, however. And it’s increasingly thought that the tumor with the most aggressive features — called the index lesion — dictates how a man’s cancer […] The post An emerging treatment option for men with recurring prostate cancer after radiation therapy appeared first on Harvard Health Blog.
harvard - 2 weeks ago
Joint Pain, Aging, and Arthritis - Understand Your Pain  - web md

Joint Pain, Aging, and Arthritis - Understand Your Pain

Creaking knees, hips, and ankles aren't necessarily normal aches and pains that come with age. Your pain might be arthritis. Luckily, medicine has a lot to offer --- from exercise and alternative supplements to medications and joint replacement.
web md - 2 weeks ago
Birx: Most COVID Deaths Could Have Been Avoided  - web md

Birx: Most COVID Deaths Could Have Been Avoided

Birx said that although many of the first 100,000 deaths in the initial COVID-19 wave were likely inevitable, the deaths from the later waves could have been reduced if the U.S. had implemented lockdown measures sooner and taken safety protocols more seriously throughout 2020.
web md - 2 weeks ago
FAQ: What to Know About COVID-19 Vaccines for Kids  - web md

FAQ: What to Know About COVID-19 Vaccines for Kids

As more adults across the country get vaccinated against COVID-19, researchers are turning their attention to studying the vaccine in children and teens. Trials are now underway in the U.S. in children as young as 6 months.
web md - 2 weeks ago
Simple, low-cost, low-tech brain training - harvard

Simple, low-cost, low-tech brain training

Mentally stimulating activities help the brain create new connections that may prevent cognitive decline as people get older, and there are plenty of simple, low-tech ways to sharpen your thinking that are budget-friendly. The post Simple, low-cost, low-tech brain training appeared first on Harvard Health Blog.
harvard - 2 weeks ago
A Stressed Brain Linked to

A Stressed Brain Linked to 'Broken Heart' Syndrome

The brain may play a role in so-called broken heart syndrome, a new study suggests. Formally known as Takotsubo syndrome (TTS), it's a temporary -- but potentially deadly -- heart condition brought on by stressful situations and emotions.
web md - 3 weeks ago
What your workplace should learn from COVID - positive sharing

What your workplace should learn from COVID

I had a great talk yesterday with the awesome Rich Sheridan about the post-COVID workplace for the latest Heartcount webinar. Here’s the entire video of our conversation – he shares some phenomenal tips!
Peloton Spurs High-Tech, High-Dollar Home Fitness Trend  - web md

Peloton Spurs High-Tech, High-Dollar Home Fitness Trend

These expensive machines use high-tech home equipment, interactive video screens and trackers, trainers, and the enthusiasm found in group classes. They’re generally expensive and involve a subscription service. But lower-priced versions are sprouting up
web md - 3 weeks ago
Senate Confirms First Openly Transgender U.S. Official  - web md

Senate Confirms First Openly Transgender U.S. Official

The vote Wednesday was 52-48 and the result was mostly along party lines. Only two Republicans -- Sens. Lisa Murkowski of Alaska and Susan Collins of Maine -- voted with all Democrats in supporting Levine, the Associated Press reported.
web md - 3 weeks ago
Top JAMA Editor Out Amid Podcast Investigation  - web md

Top JAMA Editor Out Amid Podcast Investigation

The American Medical Association’s Joint Oversight Committee announced that Howard Bauchner, MD,  is on leave beginning at the end of the day. Bauchner is the top editor at JAMA, the journal of the AMA.
web md - 3 weeks ago
Biden to Announce $81 billion for School Reopening  - web md

Biden to Announce $81 billion for School Reopening

White House officials say President Joe Biden will announce the government will spend $81 billion to help schools get back to in-person learning -- a step toward his stated goal of reopening schools within the first 100 days of his presidency.
web md - 3 weeks ago
Postpartum Bleeding Doesn

Postpartum Bleeding Doesn't Mean Hysterectomy

Heavy bleeding following birth can threaten the life of the mother, and doctors at times turn to a hysterectomy to end the bleeding. But a new study suggests a less invasive, underused procedure might be a better, less drastic option.
web md - 3 weeks ago
What You Should Know About Blood Glucose Tests as You Age  - web md

What You Should Know About Blood Glucose Tests as You Age

What’s a blood glucose test for? What kind of blood glucose test do I need? Which blood glucose tests are best for older adults? How do I use my blood glucose test? Find out what types of glucose tests you can use and how checking your blood sugar may change as you age.
web md - 3 weeks ago
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The sequence of hormonal therapy and radiation affects outcomes in men treated for prostate cancer

The sequence of hormonal therapy and radiation affects outcomes in men treated for prostate cancer

harvard - 4 months ago

A common treatment for men with intermediate-risk prostate cancer is to combine radiation with drugs that block testosterone a hormone that makes the tumors grow faster. (This type of treatment is also called androgen deprivation therapy, or ADT).

New research is suggesting the sequence of these treatments may be crucially important.

Dr. Dan Spratt, a professor of radiation oncology at the University of Michigan, led the research. He and his colleagues pooled data from two previously published clinical trials (here and here). Taken together, the studies enrolled just over 1,000 men who had been randomly assigned to one of two groups:

  • hormonal therapy given before radiation (followed in all cases by both treatments given together), or
  • hormonal therapy that started either concurrently with radiation and then continued after it was finished, or that started only after the radiation treatments were completed.

By themselves, the individual studies didn’t show a significant difference in outcomes after an average follow-up of nearly 15 years. But by pooling the data, Spratt’s team produced a dataset with enough statistical power to show that men who started on hormonal therapy either during or after radiation did significantly better in all respects: compared to the men who were treated with hormone therapy first, they had lesser odds of experiencing a rise in prostate-specific antigen levels (suggesting the cancer might be returning); they lived longer without a progression of their disease; and they were less likely to have cancer spread to other parts of the body. The results also suggested they had a lower risk of actually dying from prostate cancer, although this particular finding wasn’t statistically significant.

Researchers have already devoted a lot of attention to how long hormonal therapy should last when it’s given with radiation. This is now the first study to show that sequence also matters.

Why would that be the case? Possible explanations center on testosterone’s capacity to fix genetic damage in irradiated cancer cells. Just how sequencing plays into this repair mechanism isn’t known, but Dr. Spratt says the new results point to avenues for further study.

Importantly, the results apply specifically to men with unfavorable intermediate-risk prostate cancer who typically get four to six months of hormonal therapy. According to Spratt, sequencing may not be as relevant to men with high-risk tumors who can get hormonal treatments for several years.

Dr. Marc Garnick, the Gorman Brothers Professor of Medicine at Harvard Medical School and Beth Israel Deaconess Medical Center, editor of the Harvard Health Publishing Annual Report on Prostate Diseases, and editor in chief of HarvardProstateKnowledge.org, says there are circumstances in which some men will need hormonal therapy before radiation. Describing the new results as compelling, he adds “Efforts to investigate sequencing prospectively (i.e., forward in time) should become an important component of future research.”

The post The sequence of hormonal therapy and radiation affects outcomes in men treated for prostate cancer appeared first on Harvard Health Blog.

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